Finally I got downloaded the ancient La Braña genome. It is publicly available from the NCBI sequence read archive. I refined it by GATK, a program reading genome sequences and calling SNPs. A bit over 1 million SNPs were called, over 100k overlapped with the 1M Illumina set used by 23andme, but only 20 kSNP’s overlapped with my standard LD-pruned set. It is less than some other projects have been able to reach, but still usable, although some amount of inaccuracy is seen in individual results. The big view and locations of populations on MDS-plots are still very correct.
Playing around with PCA, which I have used earlier, I found it being poorly applicable in this case and I moved to MDS. It was obvious that the LaBrana1 sample being something different than any present-day population didn’t share as much common SNP-level principal components with them as MDS can retrieve using genetic distances.
Comparing to other online results shows some similarity and also differences. What made me pondering was the obvious Asian affinity of LaBrana1 shown on the Eurasian plot. This Asian affinity was shown around at the same level with most eastern Russians, like most eastern samples from Vologda and most eastern Mordvins. This is very close what I have seen achieved by some other projects, but surprisingly Lazaridis et al. didn’t show Asian affinity for LaBrana1. Unfortunately he didn’t inform us about the amount of SNPs used on his PCA-plot (or I didn't find it), but the study tells that only a 10 kSNP overlapping set was obtained for LaBrana1 and even less for some other ancient samples. But maybe I am wrong. Maybe I know more after testing other ancient WHG samples.
MDS plottings and IBS-statistics show closest similarity with Northern European populations. My data lacks of Basques, so I can’t say how close the LaBrana1 they might be. In general South Europeans are more distant for LaBrana1 than North Europeans and Near Easteners are even more distant. The closest population at average IBS-level was Western/Southwestern Finns, but the difference to Estonians and Lithuanians was quite small.
Fulls size image available here
Full size image available here
IBS-statistics for top ten individuals
IBS average statistics including all population from my extended European data set (East and North Asians excluded)